This post explains how to study and measure psychological safety in medication conversations using qualitative data and AI tools. The primary keyword is psychological safety in medication conversations, and the audience is qualitative researchers, implementation scientists, and health services teams. According to PLOS ONE (El-Kotob et al., 2026), patient psychological safety influences whether people ask questions, report concerns, and participate in medication decision-making, which makes it a high-priority outcome for medication safety research.
Key Takeaways
According to PLOS ONE (El-Kotob et al., 2026), patients reported that feeling heard, receiving clear medication information, and being invited into decisions increased psychological safety during medication conversations: "Patients may be more willing to discuss medication-related experiences when they feel psychologically safe during healthcare encounters, " El-Kotob et al., PLOS ONE (2026).
- The PLOS ONE study interviewed 21 adults between May and August 2024, with results published on August 20, 2026, and used the Patient Psychological Safety (PPS) framework to code belonging, learning, and participation.
- In the PLOS ONE sample (El-Kotob et al., 2026), 19 of 21 participants were aged 40 or older, 14 identified as women, and 14 identified as White, which authors flagged as a limitation for transferability.
- Participants in PLOS ONE described concrete barriers such as feeling dismissed or embarrassed; one participant said, "I was disbelieved and dismissed" (Participant P02, PLOS ONE, 2026).
- For qualitative teams, PLOS ONE (El-Kotob et al., 2026) shows that targeted interview prompts about belonging, learning, and participation produce analyzable patterns that link communication behaviors to medication safety outcomes.
What happened: study design and measures
According to PLOS ONE (El-Kotob et al., 2026), researchers conducted a qualitative secondary analysis of interviews and focus groups collected between May 1, 2024 and August 31, 2024, in Ontario, Canada.
According to PLOS ONE (El-Kotob et al., 2026), the sample included 21 adults who had taken at least one prescribed medication for three months or longer, and data collection used semi-structured interviews and virtual focus groups via Zoom or telephone.
According to PLOS ONE (El-Kotob et al., 2026), the analysis was deductive, guided by the Patient Psychological Safety (PPS) framework with domains Patient Belonging, Patient Learning, and Patient Participating, and coding used a data display matrix in Microsoft Excel.
Findings snapshot
| Date | Metric | Value | Implication |
|---|---|---|---|
| May–Aug 2024 | Participants interviewed | 21 | PLOS ONE (El-Kotob et al., 2026) produced rich qualitative data suitable for framework-driven analysis |
| Aug 20, 2026 | Publication date | PLOS ONE article published | Findings are citable and available for replication and tool-building |
| May–Aug 2024 | Age ≥40 | 19 of 21 participants | Sample skew limits generalizability to younger adults (PLOS ONE, 2026) |
| May–Aug 2024 | Gender and race counts | 14 identified as women, 14 identified as White | Authors report demographic homogeneity as a study limitation (PLOS ONE, 2026) |
Implications for qualitative researchers and health teams
Answer-first: Qualitative teams should code for belonging, learning, and participation when analyzing conversations about medications, because PLOS ONE (El-Kotob et al., 2026) shows these constructs map directly to patient willingness to ask questions and engage.
According to PLOS ONE (El-Kotob et al., 2026), prompts that elicit examples of being heard, feeling dismissed, or being invited into decisions generate actionable excerpts that tie communication behaviors to safety risks.
According to PLOS ONE (El-Kotob et al., 2026), researchers should plan purposive sampling to include younger adults and racially diverse participants because the study sample (n = 21) was majority older and White and authors flagged limited transferability.
According to the World Health Organization (Medication Without Harm, 2017), improving medication conversations supports the global medication safety agenda, which reinforces the practical value of studying psychological safety in this context.
How Evidano helps
Definition and platform fit
Evidano is an AI-powered qualitative data analysis platform that helps researchers analyze interviews, open-ended surveys, and documents.
According to PLOS ONE (El-Kotob et al., 2026), rich interview excerpts about feeling dismissed or supported are central to assessing patient psychological safety; Evidano can ingest transcripts and surface these excerpts automatically using thematic and content-frequency analysis.
For teams preparing transcripts, Evidano supports automated transcription with custom dictionaries and PII redaction, useful when working with sensitive medication narratives; see the Evidano speech-to-text feature for details.
Problem: Fragmented data and slow synthesis → Solution: Thematic + cross-segment analysis
Problem: PLOS ONE (El-Kotob et al., 2026) highlights how medication conversations are distributed across providers and encounters, creating fragmented qualitative data.
Solution: Evidano can merge multiple transcripts and documents, run thematic coding across segments (for example, by provider type or patient demographic), and produce frequency and co-occurrence visualizations to show where psychological safety breaks down.
Problem: Identifying micro-excerpts of psychological harm → Solution: AI-assisted quote extraction
Problem: PLOS ONE participants described concise, high-signal quotes such as "I was disbelieved and dismissed" (Participant P02, PLOS ONE, 2026) that are critical for reporting.
Solution: Evidano's AI chat and excerpt extraction surfaces verbatim quotes and links them to codes and timestamps so research teams can assemble evidence-rich reports efficiently, and team members can verify context directly against source transcripts.
Problem: Need for reproducible framework-driven coding → Solution: Framework templates and audit trails
Problem: PLOS ONE (El-Kotob et al., 2026) used the PPS framework and a matrix in Excel; reproducibility is harder with manual matrices.
Solution: Evidano supports hierarchical codebooks (framework → subcodes), exportable audit trails, and collaborative coding so teams can reproduce the PPS mapping and report inter-coder decisions.
Data governance and ethics
Problem: PLOS ONE (El-Kotob et al., 2026) restricted sharing of identifiable raw data because of ethics approvals, a common constraint in medication research.
Solution: Evidano encrypts data, does not use customer data to train third-party models, and provides role-based access to support ethical, audit-ready analysis; see Evidano data security for details.
Learn more
For a feature overview that matches the use cases above, see the Evidano features page.
FAQ: psychological safety in medication conversations
What is patient psychological safety in medication conversations?
Answer-first: Patient psychological safety is the perception that a patient can voice concerns, ask questions, and participate in decisions without fear of negative consequences, according to Rathert et al. and operationalized in the PPS framework used by PLOS ONE (El-Kotob et al., 2026).
Supporting detail: The PPS framework used in PLOS ONE includes Patient Belonging, Patient Learning, and Patient Participating as core domains for coding conversation excerpts.
How did the PLOS ONE study measure psychological safety?
Answer-first: The PLOS ONE study measured psychological safety qualitatively by deductively coding interview and focus group transcripts into the PPS framework, according to El-Kotob et al., PLOS ONE (2026).
Supporting detail: Data were collected via semi-structured interviews and focus groups between May and August 2024, transcribed and coded in a matrix aligned with PPS constructs.
Can AI tools reliably detect psychological safety in transcripts?
Answer-first: AI tools can accelerate detection of psychological safety signals but require human validation, a conclusion supported by the analytic needs highlighted in PLOS ONE (El-Kotob et al., 2026).
Supporting detail: PLOS ONE shows the importance of context and participant identity when interpreting quotes like "I was disbelieved and dismissed" (Participant P02, PLOS ONE, 2026), which is why AI extraction plus human review is recommended.
What sample and recruitment strategies are appropriate for this topic?
Answer-first: Purposive sampling that ensures demographic and experiential diversity is appropriate because PLOS ONE (El-Kotob et al., 2026) cautions that a mostly older, White sample (n = 21) limits transferability.
Supporting detail: The PLOS ONE authors recommend future studies examine intersections of race, gender, disability, and socioeconomic status to capture variation in psychological safety experiences.
How should teams report quotes about psychological safety?
Answer-first: Teams should present short verbatim quotes with source labels and contextual codes, because PLOS ONE (El-Kotob et al., 2026) demonstrates the power of concise participant phrases for illustrating findings.
Supporting detail: Examples from PLOS ONE include quotes such as "I try to treat providers respectfully... And they treat me as an equal" (Participant P10, PLOS ONE, 2026) which link directly to the belonging domain.
Conclusion & Next Steps
Psychological safety in medication conversations maps to measurable interview patterns of being heard, understanding medication information, and participating in decisions, according to PLOS ONE (El-Kotob et al., 2026).
Qualitative research teams should adopt a framework-driven codebook, purposive sampling for diversity, and AI-assisted synthesis balanced by human validation to produce reproducible, actionable findings, reflecting recommendations in PLOS ONE (El-Kotob et al., 2026).
If you want to pilot AI-enabled qualitative workflows for studying psychological safety in medication conversations, see Evidano features and speech-to-text for practical next steps.
Ready to try this on your data? Try Evidano for free.
Topics
- psychological safety in medication conversations
- patient psychological safety
- qualitative analysis of medication discussions
- AI qualitative research
Keep reading
- Commentary on NewsPsychological safety in medication conversationsSummarizes a PLOS One qualitative study on psychological safety in medication conversations and shows how AI-enabled qualitative research speeds synthesis and insight.
- Commentary on NewsSafer Medication Talks: psychological safety in medicationsHow psychological safety in medication conversations improves patient engagement and safety, with quotes and stats from the 20 Aug 2026 PLoS One study. Practical steps and tools.
- Commentary on NewsImprove Patient Psychological Safety in Medication TalksPractical guidance for qualitative researchers on patient psychological safety in medication conversations, with PLOS One statistics, quotes, and AI analysis tips.
